Analysis of Gene Expression Data Spring Semester , 2007 Lecture 9 : June 21 , 2007
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چکیده
There are two central approaches in addressing this problem: The first approach tries to find out the relation between two specific genes. An example of this approach is the usage of 2-hybrid systems [1]. The second approach takes ”snapshots” of the expression levels of many genes in different conditions, and tries to describe the network of relations between genes that will fit these observations. An example of this approach is the usage of DNA microarray, commonly used to monitor gene expression at the level of mRNA. The main contribution of this technology is that numerous genes can be monitored simultaneously, making it possible to perform a global expression analysis of the entire cell. In this scribe we will cover techniques related to the second approach. Genes and proteins functionalities and interactions can be examined by causing perturbations to genes in the network. There are two possible types of perturbations:
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